Host SUMOylation Pathway Negatively Regulates ...

2022年7月25日 — Activation and transfer to UBC9 involve the formation of thioester bonds between C-terminus of mature SUMO and specific Cys (C) residues at ...

Sumoylation Pathway. The small ubiquitin like modifier (SUMO) conjugation pathway modifies hundreds of proteins that participate in diverse cellular processes, ...

由 J Singhal 著作 · 2022 · 被引用 5 次 — Here, we are reporting the role of host SUMOylation in regulating various defense and immune responses from macrophages during leishmaniasis.

由 G Joshi 著作 · 2021 · 被引用 21 次 — SUMOylation of IRF3 and IRF7 acts as a negative regulator of the type-I interferon pathway leading to reduced interferon production. SUMO- ...

由 JR Gareau 著作 · 2010 · 被引用 1253 次 — The SUMO proteins share structural similarities with ubiquitin, and their conjugation to substrates occurs through a related enzymatic cascade ...

SUMOylation is a reversible post-translational modification involving the covalent attachment of a small ubiquitin-like modifier (SUMO) protein to lysine ...

由 L Wang 著作 · 2021 · 被引用 6 次 — SUMO is a necessary pathway for almost all eukaryotic cells, and aberrant expression or activity of different components in the SUMO pathway may ...